Osteoid is a bone protein matrix that is composed mainly of type 1 collagen. Osteoid builds up due to the fact that it does not mineralize properly when you have osteoblast or mineral dysfunction that is insufficient.
Your growth plate becomes irregular, thick and wide when the newly made bone of your growth plate does not mineralize. This results in a clinical diagnosis of rickets. This is true only in the case of children because adults do not have growth plates any longer.
Osteomalacia occurs when your remodeled bone does not mineralize. Osteomalacia is a condition that takes place in all ages. Many of the hereditary causes of osteomalacia show up during childhood and result in rickets.
Osteomalacia is characterized by a softening of your bones. In fact, that is what the meaning of osteomalacia is, “soft bones.”
Soft bones have a greater tendency to bow and fracture than harder, healthy bones do. When you have osteomalacia, your bone is prone to break down faster than it can re-form.
Osteomalacia and osteoporosis are not the same thing. Osteoporosis is another bone ailment that can also lead to bone fractures. Osteomalacia results from a defect in your bone-building process. Osteoporosis is caused by a weakening of previously constructed bone.
Frame syndrome is a rare kind of osteomalacia. It is a condition that is evidenced by an enzyme defect that affects bone formation. Frame syndrome mainly involves your ribs and your hip bone (iliac crest).
There is a racial predilection with frame syndrome. This condition takes place most of the time in Caucasians and blacks.
Frame syndrome is referred to in other ways. It is also called atypical osteomalacia involving the axial skeleton and axial osteomalacia.
In order for you to build strong, healthy bones, your body must have calcium and phosphate. Frame syndrome may develop if you do not receive enough of these two minerals from your diet or your body does not absorb these minerals properly.
There are several things that may result in these problems. Some of these things are:
- Taking certain drugs that are used in the treatment of seizures, such as Phenobarbital and phenytoin
- Having kidney or liver diseases
- Having a Vitamin D deficiency
- Having certain surgeries, such as gastrectomy (removing all or a part of your stomach)
- Having an autoimmune disease that is known as celiac disease.
There are several signs and symptoms that you may have with frame syndrome. Some of these may include:
- Tenderness that occurs over the area of your lumbar spine
- A limited range of motion in the area of your spine
- Back pain
- Chronic axial pain that is vague
- Fatigue that takes place in your extremities
- Impairment in the formation of your bone
- Osteomalacia of your hip bone (iliac crest)
- Osteomalacia of your rib
- Fragility of your bones
- Weakness in your muscles
- Weakness in your legs and arms
- Diffuse body pains
- A reduction in your ability to get around
- A waddling gait when you walk.
- Axial Osteomalacia and Receiving Social Security Disability (disabilitycasereview.com)
- Idiopathic Fibrous Hyperplasia Bone Disease and Disability (disabilitycasereview.com)