Antiphospholipid Syndrome and Receiving Social Security Disability
Antiphospholipid syndrome is an ailment that is evidenced by blood coagulation. This results in thrombosis (blood clots) in both your veins and arteries. Pregnancy-related complications can also develop, such as preterm delivery, severe preeclampsia or miscarriage.
Antiphospholipid syndrome results from the autoimmune production of antibodies against phospholipid (aPL). This is a cell membrane substance. In particular, the syndrome is evidenced by antibodies that are formed against cardiolipin (anti-cardiolipin antibodies) and ?2 glycoprotein I.
Primary antiphospholipid syndrome is the term that is used when this syndrome occurs in the absence of any other related disease. It is known as secondary antiphospholipid syndrome when it develops in conjunction with other autoimmune diseases like lupus. In rare cases, antiphospholipid syndrome causes rapid organ failure that is due to generalized blood clots. In these cases, there is a high risk of death. This is referred to as "catastrophic antiphospholipid syndrome".
Estimates are that 1 to 5% of the general population has antiphospholipid syndrome. This syndrome is a major concern for women as 75 to 90% of those with this syndrome are women. Antiphospholipid syndrome is responsible for 10 to 25% of recurrent miscarriages. This syndrome causes one third of all strokes that occur in people under the age of 50. Antiphospholipid syndrome causes 15 to 20% of all cases of blood clots in large veins (deep vein thrombosis).
The cause of primary antiphospholipid syndrome is unknown. However, there are some factors that are associated with developing antiphospholipid antibodies. These include:
[caption id="" align="alignright" width="300" caption="Image via Wikipedia"]
Lupus or some other autoimmune disorder is believed to be the cause of secondary antiphospholipid syndrome. An autoimmune disorder is one in which your immune system attacks your own body tissues and cells for some unknown reason.
The signs and symptoms that you experience with antiphospholipid syndrome are determined by where blood clots form in your body or where they travel to. Signs and symptoms are:
- Certain medications
- Genetic predispositions
Less common signs and symptoms include:
- Blood clots that travel to your lungs (pulmonary embolism)
- Blood clots in your legs (deep vein thrombosis)
- Recurring miscarriages or stillbirths and other complications of pregnancy.
- Mental health problems like depression or psychosis
- Sudden hearing loss
- Cardiovascular disease
- Chorea (movement disorder)
- Neurological symptoms like seizures, dementia and headaches
- Cognitive problems like poor memory.