Factor V Leiden is an inherited genetic disorder that may increase your risk of having abnormal thrombophilia (blood clots). This occurs primarily in your veins.
Many people with factor V Leiden never have abnormal blood clots. On the other hand, some people with factor V Leiden have blood clots that can be life-threatening or result in long-term health difficulties.
Factor V Leiden is named after the city of Leiden in the Netherlands. This is where it was first identified in 1994 by Professor R. Bertina et al.
Unfortunately, factor V Leiden is a common inherited genetic disorder. About 5% of Caucasians in North America have this disorder. Factor V Leiden is less common in Blacks, Hispanics and Asians.
As just mentioned, factor V Leiden is an inherited genetic disorder. It is caused by inheriting a defective (mutated) copy of the factor V gene. If you inherit one copy of the defective gene (heterozygous) from one of your parents, your risk of having abnormal blood clots is only slightly increased. If you inherit a mutated gene from each of your parents (homozygous), your risk is significantly increased.
You may never have any signs or symptoms with factor V Leiden. However, if you do have signs and symptoms, they will probably depend on where your blood clot develops and whether it moves and where it goes in your body.
Signs and symptoms of a blood clot that is located close to the surface of your skin may include:
§ Pain or tenderness that is usually located in or around the vein that has the blood clot
Signs and symptoms of a blood clot that is located in a deep vein include:
§ Prominent swelling
Signs and symptoms of a blood clot that goes to your lungs are:
§ A cough that produces blood-streaked or bloody sputum
§ Sudden shortness of breath
§ Tachycardia (rapid heartbeat)
§ Chest pain that occurs when you are breathing in.
You or a loved one may have factor V Leiden. Factor V Leiden and/or complications that have resulted from or other disabling conditions along with this disorder may be the reason for you or your loved ones disability.
If this is true, you may need assistance. You may need financial help.
You or your loved one may have decided to apply for the financial assistance that you need from the Social Security Administration by applying for Social Security disability benefits or disability benefits because of the disability caused by factor V Leiden and/or complications that have resulted from or other disabling conditions along with this disorder. You or your loved one may have already tried this option and been denied by the Social Security Administration.
If you or your loved one intends to reapply or appeal the denial, think about this. People who are represented by a disability attorney like the one you will find at Disability Case Review are approved more often than people who do not have a disability lawyer fighting for them.